Louisville Rallies Past Florida State 44-20 Behind Isaac Brown's 235 Rushing Yards
Louisville turned a disastrous opening quarter into a dominant ACC victory Friday night, rallying from a 14-point deficit to defeat Florida State 44-20 at L&N Federal Credit Union Stadium.
Running back Isaac Brown rushed for a career-high 235 yards and two touchdowns on 17 carries, including a record-breaking 97-yard touchdown run that transformed the game.
The Cardinals scored 35 unanswered points after falling behind 14-0, improving to 3-3 overall and 2-2 in ACC play while snapping a two-game losing streak.
Florida State dropped to 3-3 overall and 1-2 in conference competition despite another productive performance from quarterback Ashton Daniels.
Florida State Builds Early 14-0 Lead
Florida State opened the game with an impressive 14-play, 75-yard touchdown drive.
The Seminoles established their rushing attack immediately, running the ball on 11 plays during the possession.
Daniels completed the drive with a seven-yard touchdown run, giving Florida State a 7-0 advantage.
The Seminoles' defense then stopped Louisville on fourth-and-one, allowing their offense to regain possession near midfield.
Daniels capitalized with another scoring drive.
Facing fourth-and-four, he connected with wide receiver Micahi Danzy to extend the possession.
On the following play, Danzy made a spectacular one-handed reception for a 25-yard touchdown, extending Florida State's lead to 14-0.
The Seminoles appeared positioned to take complete control when they advanced inside Louisville's five-yard line early in the second quarter.
Instead, the game changed dramatically.
Isaac Brown's 97-Yard Touchdown Changes Everything
Florida State faced fourth-and-goal near Louisville's two-yard line with an opportunity to extend its advantage to three touchdowns.
Daniels completed a short pass to Jasen Lopez, but Louisville defensive back Kaleb Beasley stopped him short of the goal line.
The defensive stand gave Louisville possession deep in its own territory.
On the very next play, Brown exploded through the Florida State defense for a 97-yard touchdown run.
The remarkable play established a new Louisville program record for the longest play from scrimmage, surpassing the previous 93-yard mark set in 1958.
More importantly, it completely changed the momentum.
Instead of trailing 21-0, Louisville had reduced the deficit to 14-7 with 9:16 remaining in the second quarter.
The Cardinals' defense responded with improved execution, preventing Florida State from extending its advantage.
Louisville eventually tied the game when Marquise Davis scored on a three-yard touchdown run with 3:21 remaining before halftime.
After trailing by two touchdowns, the Cardinals entered the break tied 14-14.
Louisville Takes Control in Third Quarter
Louisville carried its momentum into the second half.
Brown opened the third quarter with a 71-yard kickoff return that positioned the Cardinals deep in Florida State territory.
A penalty added additional yardage, creating an immediate scoring opportunity.
Quarterback Lincoln Kienholz capitalized with a three-yard touchdown run, giving Louisville its first lead at 21-14.
The Cardinals continued applying pressure.
On their next scoring possession, Kienholz finished an eight-play, 76-yard drive with a one-yard touchdown run.
Louisville extended its advantage to 28-14, completing a dramatic turnaround after struggling throughout the opening quarter.
The Cardinals' rushing attack repeatedly created problems for Florida State, while their defense prevented the Seminoles from regaining their early offensive rhythm.
Cardinals Complete 35-Point Scoring Run
Louisville continued its offensive dominance early in the fourth quarter.
Running back Braxton Jennings broke free for a 44-yard touchdown run, extending the Cardinals' advantage to 35-14.
The score completed an extraordinary stretch in which Louisville produced 35 consecutive points after falling behind 14-0.
Florida State finally responded with a 10-play, 79-yard touchdown drive.
Daniels connected with Jayvan Boggs for a 22-yard gain on fourth-and-seven before finding Ousmane Kromah and Landen Thomas for additional first downs.
The possession ended with a two-yard touchdown pass to Danzy, reducing Louisville's lead to 35-20.
However, the Cardinals immediately answered.
Brown delivered another explosive rushing touchdown, this time from 58 yards, effectively ending Florida State's comeback hopes.
Carson Hilbert later added a 39-yard field goal to complete Louisville's 44-20 victory.
Isaac Brown Delivers Career-Best Performance
Brown's performance was the centerpiece of Louisville's remarkable comeback.
The junior running back finished with 235 rushing yards and two touchdowns on just 17 attempts.
His 97-yard touchdown represented the longest play from scrimmage in Louisville history, while his 58-yard fourth-quarter score demonstrated his ability to break open the game repeatedly.
Brown's 235 rushing yards were also the highest single-game total by an FBS running back at that point in the 2026 season.
His production became even more important because Louisville entered the matchup without injured running back Keyjuan Brown.
Despite that absence, the Cardinals dominated on the ground.
Louisville finished with 397 rushing yards and 537 total offensive yards.
The rushing total was the program's highest since producing 411 yards against Syracuse in November 2018.
The Cardinals generated all six of their touchdowns on the ground.
Lincoln Kienholz and Louisville's Rushing Attack Shine
Although Brown delivered the biggest plays, Louisville received important contributions throughout its offense.
Kienholz completed 11 of 15 passes for 140 yards while adding 40 rushing yards and two touchdowns.
His third-quarter scoring runs helped Louisville turn a halftime tie into a commanding lead.
Davis contributed the game-tying touchdown before halftime, while Jennings added the 44-yard fourth-quarter score.
Louisville's offensive balance forced Florida State to defend multiple rushing threats.
The Cardinals also received a stronger defensive performance after their difficult opening quarter.
Stanquan Clark and T.J. Capers recorded 10 tackles apiece, helping limit Florida State's offensive opportunities.
Beasley added a late interception, his fourth of the season, after making the crucial fourth-down stop that preceded Brown's record-setting touchdown.
Ashton Daniels Sets Florida State Quarterback Record
Despite the defeat, Daniels reached an important milestone for Florida State.
The fifth-year quarterback completed 21 of 37 passes for 209 yards and two touchdowns.
He also rushed for 45 yards and one score.
His first-quarter touchdown was his 10th rushing touchdown of the season, establishing a new Florida State single-season record for rushing touchdowns by a quarterback.
Daniels became the first Seminole to record at least 10 rushing touchdowns in a season since Trey Benson accomplished the feat in 2023.
Kromah led Florida State's rushing attack with 88 yards on 19 carries, adding four receptions for 43 yards.
Danzy finished with four catches for 50 yards and two touchdowns.
However, Florida State struggled to sustain its early momentum after Louisville's defensive stand and Brown's historic touchdown run.
Louisville Earns Important ACC Victory
Friday's result provided Louisville with a much-needed conference victory after consecutive losses.
The Cardinals demonstrated resilience by overcoming an early 14-point deficit and responding with explosive rushing plays and improved defensive execution.
For Florida State, the defeat extended its road losing streak to 11 games.
The Seminoles must address their defensive struggles after allowing nearly 400 rushing yards and surrendering 44 points.
Louisville will travel to face Syracuse on Saturday, October 17, at 7:30 p.m. ET, with coverage scheduled on ACC Network.
Florida State will visit No. 4 Miami on October 17 at 7 p.m., with the matchup scheduled to air on ESPN.
For Louisville, Brown's record-breaking performance and the Cardinals' dominant response after falling behind could provide an important turning point in their 2026 season.









